Nature harnesses diverse chemical modifications to refine protein dynamics, ensuring optimal cellular performance and facilitating precise adaptation to dynamic environmental contexts. These chemical functionalizations on proteins, termed post-translational modifications, dictate when, where, and how proteins interact, function, and localize within cells. Understanding how these modifications influence our biological systems in depth carries significant implications across scientific fields, from research labs to clinical settings.

 

By integrating approaches and tools from chemical biology, organic chemistry, and proteomics, we aim to elucidate how post-translational modifications drive core biological processes, striving to pave the way for new therapeutic strategies that enhance human health.